Who should you notify after a cold chain break?

• A. The patients.
• B. Notify the delegate in charge of cold chain management.
• C. The public health department.
• D. The manufacturer.

Answer: (B)

When a cold chain break happens, the first step is to notify the person responsible for cold chain management. This individual has the training and authority to assess the extent of the exposure, review temperature logs and lot information, and decide the appropriate actions (quarantine, discard, or continue with specific reporting). They coordinate the next steps, including any required reporting to regulators or the manufacturer, and guide downstream communications.

Patients should not be contacted about the storage incident before a proper risk assessment and internal decision are made, since the immediate concern is product integrity and safety. Public health departments or manufacturers are involved as needed, but only after the internal escalation to the person in charge of cold chain management so the response is accurate and compliant.