Dulaglutide and liraglutide storage durations after first use: which combination is correct?

• A. Dulaglutide 7 days; Liraglutide 7 days
• B. Dulaglutide 30 days; Liraglutide 30 days
• C. Dulaglutide 14 days; Liraglutide 14 days
• D. Dulaglutide 14 days; Liraglutide 30 days

Answer: (D)

After first use, injectable GLP-1 medications have specific in-use stability windows that determine how long they can be kept at typical room temperatures safely. Dulaglutide pens should be stored at room temperature (up to 30°C) for up to 14 days once in use, then discarded. Liraglutide pens can be kept at room temperature (up to 30°C) for up to 30 days after first use.

These durations reflect stability data showing dulaglutide remains effective for about two weeks once the pen is in use, while liraglutide remains stable for about a month after opening. The other durations listed would either shorten the usable period below what stability data supports or exceed it, risking reduced potency or safety concerns.